منابع مشابه
Cytokines and pain.
BACKGROUND AND OBJECTIVES Cytokines are necessary for the inflammatory response, favoring proper wound healing. However, exaggerated proinflammatory cytokine production can manifest systemically as hemodynamic instability or metabolic derangements. The objective of this review was to describe the effects of cytokines in pain. CONTENTS This article reviews the effects of cytokines in pain. In ...
متن کاملCentral proinflammatory cytokines and pain enhancement.
Enhanced pain is a component of the 'sickness response' which is an evolutionarily adaptive constellation of responses that enhance the survival of the host. Proinflammatory cytokines mediate these sickness behaviors, and whether proinflammatory cytokines are involved in exaggerated pain has become an intriguing question. Studies suggest that spinal cord glial cells (astrocytes and microglia) a...
متن کاملNeuropathic pain and cytokines: current perspectives
Neuropathic pain represents a major problem in clinical medicine because it causes debilitating suffering and is largely resistant to currently available analgesics. A characteristic of neuropathic pain is abnormal response to somatic sensory stimulation. Thus, patients suffering peripheral neuropathies may experience pain caused by stimuli which are normally nonpainful, such as simple touching...
متن کاملRegulation of Cytokines in Cancer Pain
Copyright © 2016 Xue-Jun Song et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cancer pain possesses a major challenge in clinical treatment , yet its underlying mechanisms remain elusive. Recent advances in understanding th...
متن کاملImmunotherapy targeting cytokines in neuropathic pain
Pain is a complex warning system activated in response to potential or apparent danger and the absence of pain is detrimental. Nociceptive pain is high-threshold pain activated in the presence of intense stimuli, such as contact with a burning object, and is a protective system essential for detection of noxious stimuli. Inflammatory pain, caused by immune system activation in response to tissu...
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ژورنال
عنوان ژورنال: Brazilian Journal of Anesthesiology
سال: 2011
ISSN: 0034-7094
DOI: 10.1016/s0034-7094(11)70029-0